Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | RBP4 | P02753 | 10/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007618 | 0.80 | HTR2C (0.75) | HTR2CRBP4CHRNB2CHRNA4GAA | |
| SCHEMBL613612 | 0.79 | HTR2C (1.00) | HTR2CRBP4HTR1ASLC6A2SLC6A4 | |
| SCHEMBL30228461 | 0.79 | HTR2C (1.00) | HTR2CRBP4HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL307161 | 0.78 | HTR2C (1.00) | HTR2CRBP4HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL30853595 | 0.78 | HTR2C (1.00) | HTR2CRBP4HTR1ASLC6A2SLC6A4 | |
| Cyanide SCHEMBL27792035 | 0.77 | HTR2C (0.70) | HTR2CRBP4GAATDP1 | |
| SCHEMBL6964017 | 0.76 | TRPV6 (0.41) | HTR2CSLC6A2SLC6A4SLC6A3TRPV6 | |
| SCHEMBL1919230 | 0.73 | HTR2C (0.70) | HTR2CRBP4GAATDP1 | |
| SCHEMBL29721046 | 0.73 | HTR2C (0.70) | HTR2CRBP4GAATDP1 | |
| SCHEMBL28247607 | 0.73 | HTR2C (0.70) | HTR2CRBP4GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | claimed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | claimed |
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |