Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 4/20 | 0.31 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513500 | 0.76 | SIGMAR1 (0.53) | TRPV6HTR2CHDAC4SLC6A2SLC6A4 | |
| SCHEMBL29980126 | 0.76 | SIGMAR1 (0.53) | TRPV6HTR2CHDAC4SLC6A2SLC6A4 | |
| SCHEMBL6960036 | 0.76 | HTR2C (0.65) | TRPV6HTR2CSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL3326791 | 0.75 | SIGMAR1 (0.51) | TRPV6HTR2CHDAC4SLC6A2SLC6A4 | |
| SCHEMBL11793878 | 0.75 | TRPV6 (0.48) | TRPV6HTR2CHDAC4PDK2 | |
| SCHEMBL9036686 | 0.73 | TRPV6 (0.59) | TRPV6HTR2CHDAC4PDK2 | |
| SCHEMBL1919333 | 0.71 | HDAC4 (0.57) | TRPV6HDAC4PDK2ORAI1 | |
| SCHEMBL29721204 | 0.71 | HDAC4 (0.57) | TRPV6HDAC4PDK2ORAI1 | |
| SCHEMBL18671231 | 0.70 | HDAC4 (0.55) | TRPV6HDAC4PDK2ORAI1 | |
| SCHEMBL11798126 | 0.69 | HDAC4 (0.48) | TRPV6HDAC4PDK2ORAI1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |