Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 4/20 | 0.44 |
| ▸ | NPY1R | P25929 | 3/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL833464 | 0.86 | IDO1 (0.42) | CYP19A1SIGMAR1PREP | |
| SCHEMBL6429735 | 0.81 | CYP19A1 (0.50) | CYP19A1PLAUHTR1ASIGMAR1OPRM1 | |
| SCHEMBL9935276 | 0.79 | CYP19A1 (0.54) | CYP19A1PLAUHTR1ASIGMAR1OPRM1 | |
| SCHEMBL6427473 | 0.77 | PREP (0.50) | CYP19A1PREPNPY1RNPY5RADRA1D | |
| SCHEMBL8414318 | 0.77 | CHRM2 (0.67) | CYP19A1SIGMAR1CHRM2CHRM1CHRM3 | |
| SCHEMBL12422869 | 0.77 | ADRA1D (0.58) | CYP19A1PLAUHTR1ASIGMAR1NPY1R | |
| SCHEMBL7304447 | 0.76 | DGAT1 (0.58) | CYP19A1HTR1ASIGMAR1PREPMTNR1A | |
| SCHEMBL3406500 | 0.76 | DGAT1 (0.58) | CYP19A1HTR1ASIGMAR1PREPMTNR1A | |
| SCHEMBL7292707 | 0.76 | DGAT1 (0.58) | CYP19A1HTR1ASIGMAR1PREPMTNR1A | |
| SCHEMBL30612421 | 0.76 | DGAT1 (0.58) | CYP19A1HTR1ASIGMAR1PREPMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| EP-0194764-B1 | PESTICIDAL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-07-12 | — | — | EP | disclosed |
| EP-0194764-A1 | Pesticidal compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-09-17 | — | — | EP | disclosed |