Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | PHGDH | O43175 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6652797 | 0.92 | PHGDH (0.55) | NPC1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6650903 | 0.90 | KDM4E (0.59) | NPC1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL27467994 | 0.88 | KMT2A (0.64) | KMT2APOLBLMNAMAPTGAA | |
| SCHEMBL6651512 | 0.87 | PHGDH (0.52) | MEN1KMT2ACYP3A4CYP2C19PHGDH | |
| SCHEMBL6780801 | 0.86 | MAPT (0.47) | NPC1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6960635 | 0.86 | PHGDH (0.54) | MEN1KMT2ACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27556985 | 0.84 | MEN1 (0.63) | NPC1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6650534 | 0.82 | PHGDH (0.59) | NPC1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6965032 | 0.81 | PHGDH (0.58) | NPC1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6966994 | 0.81 | KMT2A (0.55) | KMT2APOLBLMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100354271-C | Piperazine derivatives and process for the preparation thereof | SAMJIN PHARM CO LTD (KR) | 2007-12-12 | — | — | CN | disclosed |
| EP-0850222-B1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARM CO LTD (KR) | 2003-05-28 | — | — | EP | disclosed |
| CN-1296477-A | Piperazine derivatives and process for the preparation thereof | SAMJIN PHARM CO LTD (KR) | 2001-05-23 | — | — | CN | disclosed |
| US-6028195-A | AN ANTITUMOR AGENT WITH VERY LOW TOXICITIES | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-02-22 | — | — | US | disclosed |
| EP-0850222-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1998000402-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 1998-01-08 | — | — | WO | disclosed |