Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956574 | 0.85 | SCN10A (0.54) | SCN10AABL1KDM5AKDM2BKDM4C | |
| SCHEMBL6180999 | 0.78 | TLR7 (0.49) | SCN10AMEN1KMT2AABL1RAB9A | |
| SCHEMBL1758489 | 0.77 | SCN10A (0.62) | SCN10AABL1KDM5AKDM2BKDM4C | |
| SCHEMBL25003825 | 0.76 | SCN10A (0.68) | SCN10AMEN1KMT2AABL1KDM5A | |
| SCHEMBL25002931 | 0.76 | SCN10A (0.67) | SCN10AABL1KDM5AKDM2BKDM4C | |
| SCHEMBL5956434 | 0.74 | HDAC1 (0.53) | RAB9AKDM4CNPC1KDM4EMAPT | |
| SCHEMBL19514104 | 0.73 | KDM4E (0.55) | SCN10ARAB9ANPC1TLR7KDM4E | |
| SCHEMBL11633917 | 0.73 | RAB9A (0.66) | MEN1KMT2ARAB9ANPC1KDM4E | |
| SCHEMBL2863908 | 0.72 | SCN10A (0.51) | SCN10AABL1KDM5AKDM2BKDM4C | |
| SCHEMBL29017606 | 0.72 | RAB9A (0.73) | KMT2ARAB9ANPC1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355903-A1 | PYRAZOLE DERIVATIVES AGAINST TGF OVEREXPRESSION | GLAXO GROUP LIMITED (GB) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002066462-A1 | PYRAZOLE DERIVATIVES AGAINST TGF OVEREXPRESSION | GLAXO GROUP LIMITED (GB) | 2002-08-29 | — | — | WO | disclosed |