SCHEMBL6960750

SCHEMBL6960750

NC(=N/N=C/c1ccoc1)c1cnccn1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.45
RAB9A P51151 5/20 0.38
POLB P06746 5/20 0.38
NPC1 O15118 3/20 0.38
BAZ2B Q9UIF8 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
TSHR P16473 1/20 0.37
MC4R P32245 1/20 0.37
ADRA1A P35348 1/20 0.37
MC3R P41968 1/20 0.37
TDP1 Q9NUW8 2/20 0.34
ALDH1A1 P00352 2/20 0.33
MAPT P10636 2/20 0.33
GAA P10253 2/20 0.33
USP2 O75604 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KMT2A Q03164 3/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
DNMT1 P26358 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6960746 1.00 SMN1; SMN2 (0.45) SMN1; SMN2RAB9APOLBNPC1BAZ2B
SCHEMBL6960755 1.00 SMN1; SMN2 (0.45) SMN1; SMN2RAB9APOLBNPC1BAZ2B
SCHEMBL6950318 0.80 ALDH1A1 (0.56) SMN1; SMN2RAB9APOLBNPC1BAZ2B
SCHEMBL6950321 0.80 ALDH1A1 (0.56) SMN1; SMN2RAB9APOLBNPC1BAZ2B
SCHEMBL6950327 0.80 ALDH1A1 (0.56) SMN1; SMN2RAB9APOLBNPC1BAZ2B
SCHEMBL6961085 0.76 POLB (0.62) SMN1; SMN2RAB9APOLBNPC1BAZ2B
SCHEMBL6961080 0.76 POLB (0.62) SMN1; SMN2RAB9APOLBNPC1BAZ2B
SCHEMBL6961077 0.76 POLB (0.62) SMN1; SMN2RAB9APOLBNPC1BAZ2B
SCHEMBL6955970 0.74 NPC1 (0.49) SMN1; SMN2RAB9ANPC1ALDH1A1MAPT
SCHEMBL6955964 0.74 NPC1 (0.49) SMN1; SMN2RAB9ANPC1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6379655-B1 FOR PROTECTION OF HUMAN SKIN AND/OR HAIR AGAINST THE DAMAGING EFFECTS OF ULTRAVIOLET IRRADIATION SOCIETE L'OREAL S.A. (FR) 2002-04-30 US claimed
EP-1103549-B1 Photoprotective cosmetic compositions containing aminoamidine derivatives and uses thereof OREAL (FR) 2003-06-04 EP disclosed
US-6379655-B1 FOR PROTECTION OF HUMAN SKIN AND/OR HAIR AGAINST THE DAMAGING EFFECTS OF ULTRAVIOLET IRRADIATION SOCIETE L'OREAL S.A. (FR) 2002-04-30 US disclosed
EP-1103549-A1 Photoprotective cosmetic compositions containing aminoamidine derivatives and uses thereof L'OREAL (FR) 2001-05-30 EP disclosed