Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080728 | 0.90 | REN (0.49) | MAPTTSHRFFAR1RAB9ASMN1; SMN2 | |
| SCHEMBL6042387 | 0.87 | FFAR1 (0.51) | MAPTTSHRFFAR1RAB9ASMN1; SMN2 | |
| SCHEMBL6955011 | 0.87 | REN (0.39) | MAPTTSHRFFAR1SMN1; SMN2LMNA | |
| SCHEMBL7080600 | 0.83 | MAPT (0.42) | MAPTTSHRFFAR1RAB9ASMN1; SMN2 | |
| SCHEMBL6960306 | 0.82 | REN (0.35) | RENGPR119 | |
| SCHEMBL7079374 | 0.82 | MAPT (0.41) | MAPTTSHRFFAR1RAB9ASMN1; SMN2 | |
| SCHEMBL7083148 | 0.80 | MAPT (0.40) | MAPTTSHRFFAR1RAB9ASMN1; SMN2 | |
| SCHEMBL7079998 | 0.80 | REN (0.62) | FFAR1RAB9ASMN1; SMN2NPC1TDP1 | |
| SCHEMBL6042416 | 0.79 | REN (0.60) | MAPTTSHRFFAR1RAB9ASMN1; SMN2 | |
| SCHEMBL7080785 | 0.78 | REN (0.51) | MAPTRAB9ANPC1TDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |