Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6642807 | 0.91 | EDNRA (0.43) | EDNRAEDNRB | |
| SCHEMBL8568832 | 0.87 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL6640800 | 0.87 | EDNRB (0.41) | EDNRAEDNRB | |
| SCHEMBL6643378 | 0.86 | EDNRA (0.40) | EDNRAEDNRB | |
| SCHEMBL8568463 | 0.85 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL6778008 | 0.85 | EDNRB (0.40) | EDNRAEDNRB | |
| SCHEMBL6770266 | 0.85 | EDNRB (0.39) | EDNRAEDNRB | |
| SCHEMBL8348292 | 0.85 | EDNRA (0.48) | EDNRAEDNRB | |
| SCHEMBL6772610 | 0.84 | EDNRB (0.39) | EDNRAEDNRB | |
| SCHEMBL6772130 | 0.84 | TP53 (0.39) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702012-B1 | Substituted isoxazole sulfonamides and their use as endothelin antagonists | BRISTOL MYERS SQUIBB CO (US) | 2003-10-15 | — | — | EP | disclosed |
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5827869-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |
| US-5612359-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| EP-0702012-A1 | Substituted isoxazole sulfonamides and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-20 | — | — | EP | disclosed |