Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947706 | 0.85 | MEN1 (0.38) | TACR1KDM1ARORCMEN1KMT2A | |
| SCHEMBL6954533 | 0.83 | MAOA (0.42) | KDM1A | |
| SCHEMBL6953026 | 0.82 | TACR1 (0.35) | TACR1KDM1ARORCMEN1KMT2A | |
| SCHEMBL6694605 | 0.82 | PDE4B (0.51) | TACR1PDE4BRORCMEN1KMT2A | |
| SCHEMBL951033 | 0.82 | PDE4B (0.51) | TACR1PDE4BRORCMEN1KMT2A | |
| SCHEMBL6694614 | 0.82 | PDE4B (0.51) | TACR1PDE4BRORCMEN1KMT2A | |
| SCHEMBL3065548 | 0.82 | PDE4B (0.51) | TACR1PDE4BRORCMEN1KMT2A | |
| SCHEMBL5451966 | 0.82 | PDE4B (0.51) | TACR1PDE4BRORCMEN1KMT2A | |
| SCHEMBL12602246 | 0.82 | PDE4B (0.51) | TACR1PDE4BRORCMEN1KMT2A | |
| SCHEMBL15144418 | 0.82 | PDE4B (0.51) | TACR1PDE4BRORCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |