Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.68 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8392010 | 0.98 | KDM1A (0.66) | KDM1ATRPV1HDAC1HDAC4HDAC7 | |
| SCHEMBL8012743 | 0.89 | TRPV1 (0.81) | KDM1ATRPV1HDAC1HDAC4HDAC7 | |
| SCHEMBL17064271 | 0.86 | KDM1A (0.58) | KDM1ATRPV1HDAC1HDAC4HDAC7 | |
| SCHEMBL1064492 | 0.85 | HDAC1 (0.74) | HDAC1HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL8244867 | 0.85 | HDAC1 (0.74) | HDAC1HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL20508341 | 0.84 | HDAC1 (0.69) | KDM1ATRPV1HDAC1HDAC4HDAC7 | |
| SCHEMBL10198474 | 0.84 | MAPT (0.77) | TRPV1HDAC1HDAC4HDAC7HDAC11 | |
| SCHEMBL7636110 | 0.83 | TRPV1 (0.77) | KDM1ATRPV1HDAC1HDAC4HDAC7 | |
| SCHEMBL19501635 | 0.83 | TRPV1 (0.77) | KDM1ATRPV1HDAC1HDAC4HDAC7 | |
| SCHEMBL28099312 | 0.82 | MAPT (0.74) | KDM1ATRPV1HDAC1HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |