Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 17/20 | 0.56 |
| ▸ | CTSL | P07711 | 18/20 | 0.56 |
| ▸ | CTSB | P07858 | 13/20 | 0.52 |
| ▸ | CTSK | P43235 | 13/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696104 | 0.85 | CTSL (0.79) | CTSSCTSLCTSB | |
| SCHEMBL697169 | 0.82 | CTSS (0.50) | CTSSCTSLCTSB | |
| SCHEMBL15173117 | 0.81 | CTSL (0.74) | CTSSCTSLCTSBCTSK | |
| SCHEMBL696140 | 0.81 | CTSS (0.51) | CTSSCTSLCTSB | |
| SCHEMBL15200560 | 0.79 | CTSS (0.72) | CTSSCTSLCTSB | |
| SCHEMBL696428 | 0.79 | CTSS (0.48) | CTSSCTSLCTSBCTSK | |
| SCHEMBL695061 | 0.78 | CTSS (0.44) | CTSSCTSLCTSBCTSK | |
| SCHEMBL15202523 | 0.78 | STS (0.44) | CTSSCTSLCTSBCTSK | |
| SCHEMBL694273 | 0.78 | CTSS (0.52) | CTSSCTSLCTSB | |
| SCHEMBL694346 | 0.76 | STS (0.44) | CTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | claimed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | claimed |
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |