Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965563 | 0.88 | PARP1 (0.42) | PARP1MEN1KMT2AOPRD1PTGDR2 | |
| SCHEMBL6966780 | 0.85 | KMT2A (0.47) | PARP1MEN1KMT2AOPRD1SIGMAR1 | |
| SCHEMBL6973348 | 0.85 | PARP1 (0.49) | PARP1MEN1KMT2AKDM4EOPRK1 | |
| SCHEMBL6968134 | 0.84 | UTS2R (0.40) | MEN1KMT2AOPRD1PTGDR2KDM4E | |
| SCHEMBL6962976 | 0.84 | ERCC1 (0.45) | PARP1KMT2ADRD1SIGMAR1EPHX2 | |
| SCHEMBL6972456 | 0.84 | KDM4E (0.40) | MEN1KMT2AKDM4EATMSIGMAR1 | |
| SCHEMBL6974704 | 0.82 | MAPT (0.40) | PARP1OPRD1KDM4EGHSRGAA | |
| SCHEMBL6970725 | 0.81 | SMN1; SMN2 (0.42) | MEN1KMT2AOPRD1KDM4E | |
| SCHEMBL6974644 | 0.80 | CYP1A2 (0.40) | PARP1OPRD1KDM4ESIGMAR1GHSR | |
| SCHEMBL6961296 | 0.79 | ACE (0.46) | PARP1SIGMAR1GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |