Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962485 | 0.85 | PARP1 (0.47) | PARP1GHSRKDM4ESIGMAR1OPRK1 | |
| SCHEMBL6968799 | 0.85 | LMNA (0.48) | KDM4EKMT2ATP53LMNAMTNR1B | |
| SCHEMBL6971131 | 0.85 | SIRT2 (0.43) | KDM4ESIGMAR1PTGER4PTGER2KMT2A | |
| SCHEMBL6968134 | 0.83 | UTS2R (0.40) | GHSRKDM4ESIGMAR1KMT2AMEN1 | |
| SCHEMBL6974704 | 0.79 | MAPT (0.40) | PARP1GHSRKDM4ELMNAALDH1A1 | |
| SCHEMBL6965563 | 0.79 | PARP1 (0.42) | PARP1KDM4EKMT2AMEN1 | |
| SCHEMBL6970725 | 0.79 | SMN1; SMN2 (0.42) | KDM4EKMT2AMEN1TP53LMNA | |
| SCHEMBL6974644 | 0.77 | CYP1A2 (0.40) | PARP1GHSRKDM4ESIGMAR1 | |
| SCHEMBL6961296 | 0.77 | ACE (0.46) | PARP1GHSRSIGMAR1TP53LMNA | |
| SCHEMBL6970477 | 0.77 | TNKS (0.46) | PARP1KDM4ESIGMAR1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |