SCHEMBL6974704

SCHEMBL6974704

NC(=O)C1c2cc[c]cc2CCN1C(=O)Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.40
ACE P12821 1/20 0.39
FAAH O00519 1/20 0.39
NAAA Q02083 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
TSHR P16473 2/20 0.38
BCHE P06276 1/20 0.37
HRH3 Q9Y5N1 2/20 0.37
OPRD1 P41143 1/20 0.37
PARP1 P09874 1/20 0.37
GHSR Q92847 2/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
PAX8 Q06710 1/20 0.35
ABCC4 O15439 1/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
PTGS1 P23219 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965563 0.87 PARP1 (0.42) OPRD1PARP1KDM4EGAA
SCHEMBL6970725 0.87 SMN1; SMN2 (0.42) MAPTSMN1; SMN2OPRD1KDM4EALDH1A1
SCHEMBL6968134 0.86 UTS2R (0.40) MAPTACESMN1; SMN2BCHEOPRD1
SCHEMBL6965869 0.84 ALDH1A1 (0.50) MAPTSMN1; SMN2KDM4EALDH1A1LMNA
SCHEMBL6961208 0.84 SMN1; SMN2 (0.44) SMN1; SMN2TSHRALDH1A1LMNA
SCHEMBL6966740 0.83 HDAC1 (0.39) MAPTFAAHKDM4EALDH1A1LMNA
SCHEMBL6961296 0.83 ACE (0.46) MAPTACESMN1; SMN2TSHRPARP1
SCHEMBL6962485 0.82 PARP1 (0.47) OPRD1PARP1GHSRKDM4EGAA
SCHEMBL6974644 0.81 CYP1A2 (0.40) MAPTACETSHROPRD1PARP1
SCHEMBL6961372 0.80 PARP1 (0.46) ACEPARP1KDM4EALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832069-B1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER (US) 2003-03-05 EP disclosed
EP-1181954-A2 Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion PFIZER INC. (US) 2002-02-27 EP disclosed
EP-0832069-A1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER INC. (US) 1998-04-01 EP disclosed
WO-1996040640-A1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER INC. (US) 1996-12-19 WO disclosed