Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 2/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.40 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971187 | 0.83 | MAPK1 (0.54) | MAPK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL1574919 | 0.81 | MAPK1 (0.63) | MAPK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL6969073 | 0.78 | KMT2A (0.55) | MAPK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL7230024 | 0.77 | MAPK1 (0.55) | MAPK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL7233447 | 0.77 | MAPK1 (0.55) | MAPK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL7232670 | 0.76 | MAPK1 (0.54) | MAPK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL2544046 | 0.76 | MAPK1 (1.00) | MAPK1MAPTHPGDSMN1; SMN2KMT2A | |
| SCHEMBL7230954 | 0.76 | MAPK1 (0.53) | MAPK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL7237287 | 0.75 | MAPK1 (0.52) | MAPK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL7239726 | 0.75 | MAPK1 (0.73) | MAPK1MAPTHPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784055-B1 | PYRIMIDINYLPYRAZOLE DERIVATIVE | DAIICHI SEIYAKU CO (JP) | 2003-02-12 | — | — | EP | disclosed |
| CN-1071754-C | Pyrimidinylpyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2001-09-26 | — | — | CN | disclosed |
| US-5852019-A | Pyrimidinylpyrazole derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| CN-1166833-A | pyrimidinyl pyrazole derivatives | DAIICHI SEIYAKU CO (JP) | 1997-12-03 | — | — | CN | disclosed |
| EP-0784055-A1 | PYRIMIDINYLPYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |