Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | UBE2M | P61081 | 4/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971187 | 0.83 | MAPK1 (0.54) | KMT2AMAPK1SMN1; SMN2UBE2MDCUN1D1 | |
| SCHEMBL6970997 | 0.80 | KMT2A (0.67) | KMT2AMAPK1SMN1; SMN2MAPTHPGD | |
| SCHEMBL6962499 | 0.78 | MAPK1 (0.61) | KMT2AMAPK1SMN1; SMN2UBE2MDCUN1D1 | |
| SCHEMBL20646803 | 0.76 | MAPK1 (0.58) | KMT2AMAPK1SMN1; SMN2MAPTHPGD | |
| SCHEMBL7233788 | 0.73 | MAPK1 (0.51) | KMT2AMAPK1SMN1; SMN2MAPTHPGD | |
| SCHEMBL7232670 | 0.72 | MAPK1 (0.54) | MAPK1SMN1; SMN2MAPTHPGDKDM4E | |
| SCHEMBL7240851 | 0.71 | MAPK1 (0.49) | KMT2AMAPK1SMN1; SMN2MAPTHPGD | |
| SCHEMBL7242010 | 0.70 | ALKBH1 (0.53) | KMT2AMAPK1SMN1; SMN2MAPTHPGD | |
| SCHEMBL7240740 | 0.69 | MAPK1 (0.50) | KMT2AMAPK1SMN1; SMN2MAPTHPGD | |
| SCHEMBL24920384 | 0.68 | HCRTR1 (0.47) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784055-B1 | PYRIMIDINYLPYRAZOLE DERIVATIVE | DAIICHI SEIYAKU CO (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-5852019-A | Pyrimidinylpyrazole derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0784055-A1 | PYRIMIDINYLPYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |