SCHEMBL7233447

SCHEMBL7233447

CC(=O)c1cnn(-c2ncccc2Cl)c1C

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.55
MALT1 Q9UDY8 2/20 0.44
CYP17A1 P05093 1/20 0.44
CYP1A2 P05177 1/20 0.44
MAPT P10636 2/20 0.43
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.41
NAMPT P43490 1/20 0.41
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
SLC9A1 P19634 1/20 0.40
RAB9A P51151 3/20 0.40
NPC1 O15118 2/20 0.39
PTGS2 P35354 1/20 0.39
MYC P01106 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7230024 0.83 MAPK1 (0.55) MAPK1MALT1MAPTHPGDSMN1; SMN2
SCHEMBL22558034 0.83 RAB9A (0.53) MAPTHPGDSMN1; SMN2ALDH1A1RAB9A
SCHEMBL7232670 0.82 MAPK1 (0.54) MAPK1MALT1MAPTHPGDSMN1; SMN2
SCHEMBL12977817 0.82 NAMPT (0.67) MALT1CYP1A2NAMPTALDH1A1NPC1
SCHEMBL15933201 0.81 MAPK1 (0.52) MAPK1MALT1MAPTHPGDSMN1; SMN2
SCHEMBL7237287 0.81 MAPK1 (0.52) MAPK1MALT1MAPTHPGDSMN1; SMN2
SCHEMBL16173941 0.79 KMT2A (0.51) MAPK1MALT1CYP17A1CYP1A2MAPT
SCHEMBL6962499 0.77 MAPK1 (0.61) MAPK1CYP1A2MAPTHPGDSMN1; SMN2
SCHEMBL27700500 0.77 ALKBH1 (0.48) MALT1CYP17A1CYP1A2MAPTSMN1; SMN2
SCHEMBL12528562 0.77 CYP17A1 (0.47) CYP17A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6552018-B1 As antitumor agents DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2003-04-22 US disclosed
CN-1105707-C Pyrazole derivative DAIICHI SEIYAKU CO (JP) 2003-04-16 CN disclosed
US-6169086-B1 AN ANTITUMOR AGENT FOR TREATING TUMOR RESISTANT TO 5-FLUOROURACIL TYPE DRUGS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
EP-1022270-A1 PYRAZOLE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-07-26 EP disclosed
CN-1251578-A Pyrazole derivative DAIICHI SEIYAKU CO (JP) 2000-04-26 CN disclosed