Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962675 | 1.00 | TBXAS1 (0.44) | TBXAS1CYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL6962667 | 1.00 | TBXAS1 (0.44) | TBXAS1CYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL6956907 | 0.88 | CYP19A1 (0.51) | TBXAS1CYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL6956897 | 0.88 | CYP19A1 (0.51) | TBXAS1CYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL6956904 | 0.88 | CYP19A1 (0.51) | TBXAS1CYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL6956348 | 0.85 | CYP19A1 (0.56) | TBXAS1CYP19A1CYP11B1CYP11B2KMT2A | |
| SCHEMBL6956344 | 0.85 | CYP19A1 (0.56) | TBXAS1CYP19A1CYP11B1CYP11B2KMT2A | |
| SCHEMBL6956351 | 0.85 | CYP19A1 (0.56) | TBXAS1CYP19A1CYP11B1CYP11B2KMT2A | |
| SCHEMBL10974263 | 0.76 | ALPG (0.63) | TBXAS1CYP19A1CYP11B1CYP11B2TDP1 | |
| SCHEMBL7666704 | 0.76 | ALDH1A1 (0.39) | TBXAS1CYP19A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6420375-B1 | ANTITUMOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |