⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11890489 | 0.82 | — | — | |
| SCHEMBL15136486 | 0.81 | ALOX15 (0.36) | — | |
| SCHEMBL18598077 | 0.77 | BCHE (0.34) | — | |
| SCHEMBL8057241 | 0.76 | TSHR (0.37) | — | |
| SCHEMBL175334 | 0.74 | — | — | |
| SCHEMBL13656483 | 0.74 | — | — | |
| SCHEMBL11913740 | 0.74 | CYP2D6 (0.35) | — | |
| SCHEMBL11886485 | 0.74 | CYP2D6 (0.35) | — | |
| SCHEMBL692337 | 0.73 | — | — | |
| SCHEMBL11913741 | 0.72 | SLC6A2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062773-A1 | 4,4a,5,7-TETRAHYDRO-3H-FURO[3,4-b]PYRIDINYL COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-27 | — | — | US | disclosed |
| CN-109890828-A | 4,4a,5, 7-tetrahydro-3H-furo [3,4-b ] pyridinyl compounds | 詹森药业有限公司 | 2019-06-14 | — | — | CN | disclosed |
| EP-2626374-B1 | DIENE-BASED CARBOXYLATE ANION AND SALT THEREOF, AND POLYMERIZABLE OR CURABLE COMPOSITION THEREOF | NIPPON CATALYTIC CHEM IND (JP) | 2019-05-15 | — | — | EP | disclosed |
| EP-2665716-B1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2017-03-08 | — | — | EP | disclosed |
| US-9499466-B2 | Diene-based carboxylate anion and salt thereof, and polymerizable or curable composition thereof | NIPPON SHOKUBAI CO., LTD. (JP) | 2016-11-22 | — | — | US | disclosed |
| US-8962858-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20140309429-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| US-8822455-B2 | Fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-09-02 | — | — | US | disclosed |
| US-8802871-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-08-12 | — | — | US | disclosed |
| US-20140011802-A1 | Fused Aminodihydrothiazine Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-01-09 | — | — | US | disclosed |
| US-20130197123-A1 | DIENE-BASED CARBOXYLATE ANION AND SALT THEREOF, AND POLYMERIZABLE OR CURABLE COMPOSITION THEREOF | NIPPON SHOKUBAI CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-20130197244-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-8426584-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-23 | — | — | US | disclosed |
| WO-2012100179-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | WO | disclosed |
| US-20120190848-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
| WO-2012093148-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2012-07-12 | — | — | WO | disclosed |
| EP-0970067-B1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES WITH OXYGEN LINK AS COX-2 INHIBITORS | MERCK FROSST CANADA INC (CA) | 2003-07-02 | — | — | EP | disclosed |
| US-6071954-A | AS NON-STEROIDAL ANTIINFLAMMATROY AGENT FOR TREATING INFLAMMATION; NONTOXIC | MERK FROSST CANADA, INC. (CA) | 2000-06-06 | — | — | US | disclosed |
| EP-0970067-A1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES WITH OXYGEN LINK AS COX-2 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998041516-A1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES WITH OXYGEN LINK AS COX-2 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 1998-09-24 | — | — | WO | disclosed |