Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.69 |
| ▸ | MPO | P05164 | 3/20 | 0.63 |
| ▸ | HTR1B | P28222 | 10/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974697 | 0.90 | MPO (0.60) | HTR1DMPOHTR1BHTR2ABRD4 | |
| SCHEMBL6964363 | 0.89 | MPO (0.59) | HTR1DMPOHTR1BHTR2ABRD4 | |
| SCHEMBL6960599 | 0.86 | MPO (0.56) | HTR1DMPOHTR1BHTR2ABRD4 | |
| SCHEMBL6968099 | 0.84 | HTR1D (0.55) | HTR1DMPOHTR1BHTR2A | |
| SCHEMBL6966978 | 0.82 | MPO (0.57) | HTR1DMPOHTR1BHTR2ABRD4 | |
| SCHEMBL7007317 | 0.82 | MPO (0.54) | HTR1DMPOHTR1BHTR2ABRD4 | |
| SCHEMBL6973292 | 0.82 | HTR1D (1.00) | HTR1DMPOHTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL7818127 | 0.81 | HTR1D (0.97) | HTR1DMPOHTR1BHTR2A | |
| SCHEMBL6968102 | 0.80 | HTR1D (0.48) | HTR1DMPOHTR1BHTR2ABRD4 | |
| SCHEMBL6963613 | 0.80 | HTR1D (0.72) | HTR1DMPOHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1289479-C | As 5-HT1D5-ring indole compounds of receptor ligands | ALLELIX BIOPHARMA (CA) | 2006-12-13 | — | — | CN | claimed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | claimed |
| CN-1245491-A | 5-cyclo indole compounds as 5-HT receptor ligands | ALLELIX BIOPHARMA (CA) | 2000-02-23 | — | — | CN | claimed |
| CN-1289479-C | As 5-HT1D5-ring indole compounds of receptor ligands | ALLELIX BIOPHARMA (CA) | 2006-12-13 | — | — | CN | disclosed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| CN-1245491-A | 5-cyclo indole compounds as 5-HT receptor ligands | ALLELIX BIOPHARMA (CA) | 2000-02-23 | — | — | CN | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |