Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 18/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | TACR2 | P21452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977742 | 0.92 | CCR5 (0.57) | CCR5OPRM1TACR2 | |
| SCHEMBL6976840 | 0.91 | CCR5 (0.55) | CCR5TACR2 | |
| SCHEMBL6964882 | 0.89 | CCR5 (0.53) | CCR5TACR2 | |
| SCHEMBL8292088 | 0.88 | CCR5 (0.53) | CCR5TACR2 | |
| SCHEMBL6959145 | 0.85 | TACR3 (0.54) | CCR5TACR2 | |
| SCHEMBL6964886 | 0.83 | UBE2M (0.51) | CCR5TACR2 | |
| SCHEMBL6959139 | 0.82 | CCR5 (0.57) | CCR5TACR2 | |
| SCHEMBL6976555 | 0.82 | CCR5 (0.52) | CCR5TACR2 | |
| SCHEMBL6961850 | 0.82 | TACR3 (0.48) | CCR5TACR2 | |
| SCHEMBL6963702 | 0.82 | CCR5 (0.50) | CCR5TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897913-B1 | 4-carboxamido piperidine derivatives and their use as neurokinine antagonists | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| EP-0667858-B1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LTD (GB) | 1999-08-25 | — | — | EP | disclosed |
| EP-0897913-A1 | 4-carboxamido piperidine derivatives and their use as neurokinine antagonists | ZENECA LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |