Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.53 |
| ▸ | F7 | P08709 | 1/20 | 0.51 |
| ▸ | F3 | P13726 | 1/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177794 | 0.86 | KDM4E (0.55) | KDM4EHSD17B10HPGDALDH1A1LMNA | |
| SCHEMBL6513729 | 0.82 | KDM4E (0.58) | KDM4EHSD17B10HPGDALDH1A1LMNA | |
| SCHEMBL6975235 | 0.82 | NHERF1 (0.53) | LMNAKMT2A | |
| SCHEMBL1476670 | 0.77 | PIN1 (0.63) | KDM4EHSD17B10HPGDALDH1A1LMNA | |
| SCHEMBL2421110 | 0.75 | SMAD3 (0.57) | KDM4EHSD17B10HPGDALDH1A1LMNA | |
| SCHEMBL6990262 | 0.74 | SMAD3 (0.60) | KDM4EHSD17B10HPGDALDH1A1LMNA | |
| SCHEMBL6512084 | 0.74 | PIN1 (0.58) | KDM4EHSD17B10HPGDALDH1A1LMNA | |
| SCHEMBL6518462 | 0.73 | PIN1 (0.54) | KDM4EHSD17B10HPGDALDH1A1LMNA | |
| 5-Fluoroindole-2-Carboxylic Acid SCHEMBL209759 | 0.72 | KDM4E (1.00) | KDM4EHSD17B10HPGDALDH1A1LMNA | |
| SCHEMBL378196 | 0.72 | SMAD3 (0.66) | KDM4EHSD17B10HPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937070-B1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA ITALIA SPA (IT) | 2003-12-03 | — | — | EP | disclosed |
| US-6153642-A | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-28 | — | — | US | disclosed |