Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11110839 | 0.81 | PGR (0.47) | CMA1PGRTSHRCYP3A4GRIN2D | |
| SCHEMBL9186534 | 0.77 | PGR (0.47) | CMA1PGRTSHRCYP3A4GRIN2D | |
| SCHEMBL16013667 | 0.77 | PDE3B (0.49) | CMA1PGRTSHRCYP3A4GRIN2D | |
| SCHEMBL1192728 | 0.74 | MAPT (0.57) | CA12CA9FASNTSHRCYP3A4 | |
| SCHEMBL1292035 | 0.74 | GRIA2 (0.74) | CA12CA9FASNTSHRCYP3A4 | |
| SCHEMBL1115790 | 0.73 | CMA1 (0.53) | CMA1PGRCA12CA9TSHR | |
| SCHEMBL3044845 | 0.71 | PGR (0.70) | PGRCA12CA9TSHRCYP3A4 | |
| SCHEMBL9180125 | 0.70 | TSHR (0.62) | TSHRCYP3A4HPGDMAPK1ALDH1A1 | |
| SCHEMBL11347101 | 0.69 | PDE3B (0.54) | CMA1PGRGRIN2DGRIN3BGRIN1 | |
| SCHEMBL18188327 | 0.68 | ALDH1A1 (0.47) | CMA1PGRGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |
| US-4438126-A | Lower alkanoic acid derivatives of 2-oxo-benzoxazolines and aldose reductase inhibiting compositions thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
| EP-0022317-B1 | 2-OXO-BENZOTHIAZOLINE, BENZOXAZOLINE OR INDOLINE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-09-21 | — | — | EP | disclosed |
| US-4370340-A | ANTIDIABETIC AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| EP-0022317-A1 | 2-Oxo-benzothiazoline, benzoxazoline or indoline derivatives, their preparation, and pharmaceutical compositions comprising such derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-01-14 | — | — | EP | disclosed |