Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999321 | 0.76 | TDP1 (0.50) | TDP1ALDH1A1POLBGPR35MEN1 | |
| SCHEMBL6990230 | 0.76 | TDP1 (0.50) | TDP1ALDH1A1POLBGPR35MEN1 | |
| SCHEMBL25597908 | 0.69 | CYP1A2 (0.56) | TDP1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL8119955 | 0.68 | EPHX2 (0.45) | TDP1ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL29475175 | 0.66 | TDP1 (1.00) | TDP1ALDH1A1POLBGPR35NOS1 | |
| SCHEMBL57166 | 0.66 | TDP1 (1.00) | TDP1ALDH1A1POLBGPR35NOS1 | |
| SCHEMBL3274689 | 0.65 | TDP1 (0.52) | TDP1ALDH1A1POLBGPR35MEN1 | |
| SCHEMBL31290996 | 0.65 | GPR35 (0.52) | TDP1ALDH1A1POLBGPR35MEN1 | |
| SCHEMBL28093598 | 0.64 | TDP1 (0.95) | TDP1ALDH1A1POLBGPR35MEN1 | |
| SCHEMBL3276135 | 0.63 | MAOA (0.54) | TDP1ALDH1A1GPR35MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |