Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963626 | 1.00 | PPARA (0.45) | PPARAPPARGCYP2C19MAPTCTSS | |
| SCHEMBL8139704 | 0.93 | PPARA (0.41) | PPARAPPARGCYP2C19MAPTCTSS | |
| SCHEMBL8139705 | 0.87 | PPARA (0.38) | PPARAPPARGCYP2C19MAPTCTSS | |
| SCHEMBL5568030 | 0.76 | CA1 (0.40) | PPARAPPARGMAPTCTSSCTSK | |
| SCHEMBL16096409 | 0.76 | CA1 (0.40) | PPARAPPARGMAPTCTSSCTSK | |
| SCHEMBL6242134 | 0.76 | CA1 (0.40) | PPARAPPARGMAPTCTSSCTSK | |
| SCHEMBL10980321 | 0.76 | PPARA (0.47) | PPARAPPARGMAPTCTSSCTSK | |
| SCHEMBL10973888 | 0.76 | PPARA (0.47) | PPARAPPARGMAPTCTSSCTSK | |
| SCHEMBL9058208 | 0.76 | PPARA (0.47) | PPARAPPARGMAPTCTSSCTSK | |
| SCHEMBL13342905 | 0.76 | PPARA (0.46) | PPARAPPARGCTSSCTSKATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | disclosed |
| US-5830869-A | METALLOPROTEASE INHIBITOR | PHARMACIA & UPJOHN COMPANY | 1998-11-03 | — | — | US | disclosed |