Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.38 |
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963624 | 0.87 | PPARA (0.45) | PPARAPPARGMAPTCYP2C19CTSK | |
| SCHEMBL6963626 | 0.87 | PPARA (0.45) | PPARAPPARGMAPTCYP2C19CTSK | |
| SCHEMBL8139704 | 0.85 | PPARA (0.41) | PPARAPPARGMAPTCYP2C19CTSK | |
| SCHEMBL6954692 | 0.68 | MMP3 (0.45) | MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL6954697 | 0.68 | MMP3 (0.45) | MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL5568030 | 0.66 | CA1 (0.40) | PPARAPPARGMAPTCTSKCTSS | |
| SCHEMBL6242134 | 0.66 | CA1 (0.40) | PPARAPPARGMAPTCTSKCTSS | |
| SCHEMBL16096409 | 0.66 | CA1 (0.40) | PPARAPPARGMAPTCTSKCTSS | |
| SCHEMBL9058208 | 0.66 | PPARA (0.47) | PPARAPPARGMAPTCTSKATM | |
| SCHEMBL10980321 | 0.66 | PPARA (0.47) | PPARAPPARGMAPTCTSKATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997048688-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |