Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2020840 | 0.86 | PYCR1 (0.35) | CRHR1ALDH1A1MAPTL3MBTL1HTT | |
| SCHEMBL6973837 | 0.85 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL2046515 | 0.84 | CRHR1 (0.46) | CRHR1MAPT | |
| SCHEMBL6968788 | 0.84 | CRHR1 (0.45) | CRHR1NR3C1BCHE | |
| SCHEMBL6968784 | 0.80 | NR1H2 (0.38) | CRHR1MAPT | |
| SCHEMBL2019659 | 0.78 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL6963411 | 0.77 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL2019830 | 0.75 | CSF1R (0.40) | CRHR1 | |
| SCHEMBL2019402 | 0.72 | CRHR1 (0.43) | CRHR1MAPT | |
| SCHEMBL2018947 | 0.72 | CRHR1 (0.41) | CRHR1NR3C1MAPTLMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946520-B1 | ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS | NEUROGEN CORP (US) | 2003-04-02 | — | — | EP | claimed |
| EP-0946520-B1 | ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS | NEUROGEN CORP (US) | 2003-04-02 | — | — | EP | disclosed |