SCHEMBL6964341

SCHEMBL6964341

Fc1ccc2cc(/C=C/Cn3ccnc3)sc2c1

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.46
TBXAS1 P24557 3/20 0.41
CYP11B1 P15538 6/20 0.40
CYP11B2 P19099 5/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6964350 1.00 CYP19A1 (0.46) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6964147 0.83 CYP11B1 (0.49) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6964137 0.83 CYP11B1 (0.49) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6959237 0.78 CYP19A1 (0.43) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6959242 0.78 CYP19A1 (0.43) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6955408 0.74 CYP19A1 (0.47) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6955399 0.74 CYP19A1 (0.47) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6965235 0.74 TUBB4A (0.41)
SCHEMBL6965226 0.74 TUBB4A (0.41)
SCHEMBL7667867 0.71 TBXAS1 (0.49) CYP19A1TBXAS1CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0974584-B1 FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-01-15 EP disclosed
US-6420375-B1 ANTITUMOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-07-16 US disclosed
EP-0974584-A1 FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-01-26 EP disclosed