Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955550 | 0.91 | KDM4E (0.49) | ALDH1A1POLBMAPK1SMN1; SMN2RAB9A | |
| SCHEMBL6959457 | 0.88 | MAPK1 (0.48) | ALDH1A1POLBMAPK1ALOX15SMN1; SMN2 | |
| SCHEMBL6950496 | 0.82 | RAB9A (0.45) | ALDH1A1POLBMAPK1ALOX15SMN1; SMN2 | |
| SCHEMBL6961866 | 0.81 | NPC1 (0.55) | ALDH1A1MAPK1ALOX15SMN1; SMN2RAB9A | |
| SCHEMBL6951981 | 0.81 | NPC1 (0.48) | ALDH1A1POLBMAPK1ALOX15SMN1; SMN2 | |
| SCHEMBL6959893 | 0.80 | NPC1 (0.47) | ALDH1A1POLBMAPK1SMN1; SMN2RAB9A | |
| SCHEMBL6959599 | 0.80 | ALDH1A1 (0.54) | ALDH1A1POLBMAPK1SMN1; SMN2RAB9A | |
| SCHEMBL6963535 | 0.79 | MAPT (0.49) | ALDH1A1POLBMAPK1SMN1; SMN2RAB9A | |
| SCHEMBL6950698 | 0.79 | KMT2A (0.42) | ALDH1A1POLBMAPK1GAAHTT | |
| SCHEMBL6954659 | 0.78 | MAPK1 (0.55) | ALDH1A1POLBMAPK1ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5714503-A | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 1998-02-03 | — | — | US | disclosed |
| US-5658907-A | THIOUREA VIRICIDES | MEDIVIR A/B (SE) | 1997-08-19 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |