Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6136622 | 0.84 | GPR35 (0.57) | GPR35TSHRALDH1A1TDP1NPC1 | |
| SCHEMBL29603881 | 0.82 | TDP1 (0.71) | GPR35TSHRALDH1A1TDP1NPC1 | |
| SCHEMBL1161927 | 0.82 | TDP1 (0.71) | GPR35TSHRALDH1A1TDP1NPC1 | |
| SCHEMBL535617 | 0.82 | ALDH1A1 (0.64) | ALDH1A1TDP1NPC1RECQLRAB9A | |
| Ammonia Solution, Strong SCHEMBL27735242 | 0.81 | TSHR (0.68) | GPR35TSHRALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL11111392 | 0.81 | ALDH1A1 (0.53) | GPR35TSHRALDH1A1TDP1NPC1 | |
| SCHEMBL6558521 | 0.81 | GPR35 (0.53) | GPR35TSHRALDH1A1TDP1NPC1 | |
| SCHEMBL28220465 | 0.81 | GPR35 (0.58) | GPR35TSHRALDH1A1TDP1NPC1 | |
| SCHEMBL9332762 | 0.81 | GPR35 (0.53) | GPR35TSHRALDH1A1TDP1NPC1 | |
| SCHEMBL11111389 | 0.81 | ALDH1A1 (0.53) | GPR35TSHRALDH1A1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | claimed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |