Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | DRD4 | P21917 | 8/20 | 0.48 |
| ▸ | DRD3 | P35462 | 8/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172170 | 0.90 | SLC6A1 (0.52) | SLC6A1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL6968776 | 0.88 | CHRM1 (0.59) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL5495902 | 0.85 | SLC6A1 (0.59) | SLC6A1DRD2DRD4DRD3CHRM2 | |
| Hydrochloric Acid SCHEMBL6971088 | 0.84 | SLC6A1 (0.58) | SLC6A1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL8196728 | 0.84 | SLC6A1 (0.63) | SLC6A1DRD2 | |
| SCHEMBL8196471 | 0.84 | SLC6A1 (0.63) | SLC6A1DRD2 | |
| SCHEMBL8194500 | 0.83 | CHRM1 (0.55) | SLC6A1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL8199176 | 0.82 | SLC6A1 (0.63) | SLC6A1DRD2 | |
| SCHEMBL7167660 | 0.81 | LTA4H (0.53) | SLC6A1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL8187340 | 0.81 | SLC6A1 (0.59) | SLC6A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613791-B1 | Treating migraine, neurogenic inflammation, rheumatoid arthritis or insulin resistance | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-0820451-B1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK AS (DK) | 2003-01-15 | — | — | EP | disclosed |
| US-6239148-B1 | TREATMENT OF PAINFUL, HYPERALGESIC AND/OR INFLAMMATORY CONDITIONS IN WHICH C-FIBERS PLAY A ROLE BY ELICITING NEUROGENIC PAIN, INSULIN RESISTANCE IN DIABETES MELLITUS OR AGING, INHIBIT INSULIN ANTAGONIZING PEPTIDE, | NOVO NORDISK A/S (DK) | 2001-05-29 | — | — | US | disclosed |
| US-6166009-A | N-substituted azaheterocyclic carboxylic acids and esters thereof | NOVO NORDISK A/S (DK) | 2000-12-26 | — | — | US | disclosed |
| US-6110913-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | NOVO NORDISK A/S (DK) | 2000-08-29 | — | — | US | disclosed |
| US-6071901-A | TREATING PAIN, HYPERALGESIA AND/OR INFLAMMATORY CONDITIONS IN WHICH C-FIBERS PLAY A PATHOPHYSIOLOGICAL ROLE; INHIBITION OF NEUROGENIC INFLAMMATION INVOLVING THE RELEASE OF NEURO-PEPTIDE FROM PERIPHERAL AND CENTRAL ENDINGS OF SENSORY NERVES | NOVO NORDISK A/S (DK) | 2000-06-06 | — | — | US | disclosed |
| EP-0820451-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031498-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1996-10-10 | — | — | WO | disclosed |