Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.52 |
| ▸ | MMP3 | P08254 | 8/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | MMP9 | P14780 | 2/20 | 0.51 |
| ▸ | MMP14 | P50281 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964268 | 0.94 | MMP2 (0.53) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL7129632 | 0.89 | MMP2 (0.52) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6437469 | 0.88 | MMP2 (0.63) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6964791 | 0.88 | MMP2 (0.51) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6433435 | 0.87 | MMP2 (0.52) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6433636 | 0.86 | MMP2 (0.55) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6586377 | 0.85 | MMP2 (0.51) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6439006 | 0.84 | MMP2 (0.45) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6435026 | 0.84 | MMP2 (0.51) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6434246 | 0.83 | MMP2 (0.51) | MMP2MMP3MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181017-B1 | METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-04-16 | — | — | EP | claimed |
| US-6511993-B1 | Substituted alpha-aminosulphonyl-acetohydroxamic acids which are inhibitors of zinc-dependent metalloprotease enzymes | PFIZER INC. | 2003-01-28 | — | — | US | claimed |