Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574830 | 0.78 | MAPT (1.00) | MAPTNPC1RAB9ABCHEPPARD | |
| SCHEMBL21313808 | 0.78 | MAPT (0.76) | MAPTNPC1RAB9ABCHEPPARD | |
| SCHEMBL29468769 | 0.77 | L3MBTL1 (0.51) | MAPTNPC1RAB9ABCHEPPARD | |
| SCHEMBL12267538 | 0.77 | MAPT (0.43) | MAPTNPC1RAB9ABCHEHSP90AA1 | |
| SCHEMBL693955 | 0.76 | MAPT (0.51) | MAPTNPC1RAB9ABCHEPPARD | |
| SCHEMBL11703618 | 0.76 | MAPT (0.78) | MAPTNPC1RAB9ABCHEPPARD | |
| SCHEMBL14366876 | 0.75 | MAPT (0.47) | MAPTNPC1RAB9ACYP1A2CYP2C9 | |
| SCHEMBL28758405 | 0.75 | MAPT (0.49) | MAPTNPC1RAB9ACYP1A2CYP2C9 | |
| SCHEMBL27299484 | 0.73 | RAB9A (0.46) | MAPTNPC1RAB9ACYP1A2CYP2C9 | |
| SCHEMBL3556746 | 0.73 | MAPT (0.72) | MAPTNPC1RAB9ABCHEPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421847-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124116-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |