Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 10/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27404520 | 0.84 | CREBBP (0.39) | NOS1NOS2 | |
| SCHEMBL6978059 | 0.81 | NOS1 (0.44) | NOS1NOS2 | |
| SCHEMBL6980069 | 0.81 | NOS1 (0.44) | NOS1NOS2 | |
| SCHEMBL6967461 | 0.81 | NOS1 (0.44) | NOS1NOS2 | |
| SCHEMBL6976103 | 0.77 | CTSD (0.49) | CTSDDDB1CRBN | |
| SCHEMBL6968377 | 0.77 | CTSD (0.49) | CTSDDDB1CRBN | |
| SCHEMBL16431295 | 0.77 | CTSD (0.63) | CTSD | |
| SCHEMBL6976101 | 0.77 | CTSD (0.49) | CTSDDDB1CRBN | |
| SCHEMBL27972516 | 0.75 | CTSD (0.48) | CTSDHDAC8DDB1CRBN | |
| SCHEMBL21058080 | 0.74 | CTSD (0.45) | CTSDDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6043261-A | TREATMENT OF INFLAMMATORY CONDITIONS AFFECTING THE JOINTS, FOR EXAMPLE ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CARDIOVASCULAR ISCHEMIA, DIABETES, HYPERALGESIA, CEREBRAL ISCHEMIA, THROMBOTIC STROKE, GLOBAL ISCHEMIA, NERVOUS SYSTEM DISORDERS | G. D. SEARLE & CO. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5883251-A | ENZYME INHIBITORS | G. D. SEARLE & CO. (US) | 1999-03-16 | — | — | US | disclosed |