SCHEMBL6965252

SCHEMBL6965252

CCOC(=O)c1ccc(-c2cc(O)cc(=O)o2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS O95271 1/20 0.58
MAPT P10636 6/20 0.56
NPC1 O15118 4/20 0.56
RAB9A P51151 4/20 0.56
ALDH1A1 P00352 4/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
KDM4E B2RXH2 2/20 0.56
CYP1A2 P05177 2/20 0.56
HPGD P15428 2/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
CA12 O43570 3/20 0.55
CA1 P00915 3/20 0.55
CA2 P00918 3/20 0.55
CA7 P43166 3/20 0.55
CA9 Q16790 3/20 0.55
CA14 Q9ULX7 3/20 0.55
ESR1 P03372 2/20 0.55
ESR2 Q92731 1/20 0.55
HSP90AA1 P07900 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8121356 0.79 QPCT (0.59) TNKSMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL8107735 0.77 CSNK2A2 (0.54) TNKSCA12CA9ESR1ESR2
SCHEMBL903983 0.75 ESR1 (0.89) MAPTNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL18885210 0.75 MAPT (0.71) TNKSMAPTNPC1RAB9AALDH1A1
SCHEMBL16351874 0.75 CA1 (0.73) MAPTNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL1965326 0.75 CA1 (0.73) MAPTNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL7739519 0.74 TNKS (0.71) TNKSMAPTNPC1RAB9AALDH1A1
SCHEMBL6829505 0.73 EGFR (0.62) TNKSMAPTNPC1RAB9AALDH1A1
Ethylparaben SCHEMBL28368 0.73 CA12 (1.00) MAPTNPC1RAB9AALDH1A1SMN1; SMN2
Ethylparaben SCHEMBL5311680 0.73 CA12 (1.00) MAPTNPC1RAB9AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed