Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488542 | 0.95 | OPRK1 (0.55) | OPRK1HRH3MEN1KMT2AL3MBTL1 | |
| SCHEMBL30397636 | 0.87 | L3MBTL1 (0.62) | OPRK1HRH3MEN1KMT2ALMNA | |
| SCHEMBL38658667 | 0.87 | L3MBTL1 (0.62) | OPRK1HRH3MEN1KMT2ALMNA | |
| SCHEMBL2454645 | 0.85 | OPRK1 (0.57) | OPRK1KMT2ALMNAMAPT | |
| SCHEMBL2222519 | 0.85 | MAPT (0.67) | OPRK1HRH3KDM4EKMT2ALMNA | |
| SCHEMBL7238484 | 0.84 | CHIA (0.66) | OPRK1HRH3KDM4EKMT2ALMNA | |
| SCHEMBL7241637 | 0.84 | OPRK1 (0.55) | OPRK1HRH3KDM4EKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL2222043 | 0.84 | MAPT (0.66) | OPRK1HRH3KDM4EKMT2ALMNA | |
| SCHEMBL6181431 | 0.84 | EPHX2 (0.52) | KMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL16105029 | 0.83 | OPRK1 (0.61) | OPRK1HRH3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235538-B2 | Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV | NOVO NORDISK A/S (DK) | 2007-06-26 | — | — | US | disclosed |
| US-7235538-B2 | Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV | NOVO NORDISK A/S (DK) | 2007-06-26 | — | — | US | disclosed |
| EP-0934312-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 2003-03-19 | — | — | EP | disclosed |
| CN-1088459-C | 1,4-disubstituted piperazines | NOVO NORDISK AS (DK) | 2002-07-31 | — | — | CN | disclosed |
| US-6133268-A | 1,4-disubstituted piperazines | NOVO NORDISK A/S (DK) | 2000-10-17 | — | — | US | disclosed |
| US-6040302-A | ANTIINFLAMMATORY AGENTS TREATING RHEUMATOID ARTHRITIS, MIGRAINE OR ITCHING, INSULIN RESISTANCE IN NON-INSULIN-DEPENDENT DIABETES MELLITUS AND AGEING-ASSOCIATED OBESITY | NOVO NORDISK A/S (DK) | 2000-03-21 | — | — | US | disclosed |
| US-6004961-A | ANTIINFLAMMATORY AGENTS, ANALGESICS; NON-INSULIN-DEPENDENT DIABETES; AGE-RELATED OBESITY; DIBENZO(D,G)(1,3,6)DIOXAZOCINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1999-12-21 | — | — | US | disclosed |
| CN-1234799-A | 1,4-disubstituted piperazines | NOVO NORDISK AS (DK) | 1999-11-10 | — | — | CN | disclosed |
| EP-0934312-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| US-5916889-A | ANTIDIABETIC AGENT; DIETETICS | NOVO NORDISK A/S (DK) | 1999-06-29 | — | — | US | disclosed |
| WO-1998015548-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |
| CN-1016691-B | PROCESS FOR PREPARATION OF ANTIPSYCHOTIC CYCLIC IMIDE DERIVATIVES OF 2-(4-BUTYLPIPERAZIN-1-YL) PHRIDINES | BRISTOL MYERS CO (US) | 1992-05-20 | — | — | CN | disclosed |
| US-4757073-A | Antipsychotic agents | BRISTOL-MYERS COMPANY (US) | 1988-07-12 | — | — | US | disclosed |
| US-4619930-A | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use | BRISTOL-MYERS COMPANY (US) | 1986-10-28 | — | — | US | disclosed |