Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 14/20 | 1.00 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130625 | 0.80 | TRPA1 (0.66) | TRPA1GPR84BCHEADORA3MAOA | |
| SCHEMBL7399870 | 0.80 | TRPA1 (0.66) | TRPA1BCHESLC6A3 | |
| SCHEMBL30186315 | 0.80 | TRPA1 (0.66) | TRPA1BACE1MEN1CYP3A4MAPT | |
| SCHEMBL11564552 | 0.77 | TRPA1 (0.62) | TRPA1GAAMAPTALOX15 | |
| SCHEMBL11391071 | 0.75 | TRPA1 (0.58) | TRPA1POLBGAAMAPTKMT2A | |
| SCHEMBL11391223 | 0.75 | TRPA1 (0.58) | TRPA1GAAMAPT | |
| SCHEMBL30587300 | 0.74 | TRPA1 (0.57) | TRPA1MEN1BCHEPOLBCYP3A4 | |
| SCHEMBL15570270 | 0.74 | TRPA1 (0.57) | TRPA1MEN1BCHEGAAMAPT | |
| SCHEMBL6208056 | 0.74 | TRPA1 (0.58) | TRPA1BACE1MEN1CYP1A2BCHE | |
| SCHEMBL168345 | 0.73 | TRPA1 (0.56) | TRPA1GPR84MEN1CYP1A2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120136813-A | Deuterium-labeled quetiapine fumarate isotope compound, preparation method thereof and food detection method | 曼哈格(上海)生物科技有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-114181172-B | Efficient preparation method of quetiapine fumarate | 浙江苏泊尔制药有限公司 | 2023-12-22 | — | — | CN | claimed |
| CN-114181172-A | Efficient preparation method of quetiapine fumarate | 浙江苏泊尔制药有限公司 | 2022-03-15 | — | — | CN | claimed |
| WO-2007020011-A1 | PROCESSES FOR THE PREPARATION OF THIAZEPINES | SANDOZ AG (CH) | 2007-02-22 | — | — | WO | claimed |
| WO-2006135544-A1 | SYNTHESIS OF 11-(4[-(2-HYDROXYETHOXY)ETHYL]-PIPERAZINYL)-DIBENZO[b,f][1,4]THIAZEPINE AND ITS FUMARATE SALT | CAMBREX CHARLES CITY, INC. (US) | 2006-12-21 | — | — | WO | claimed |
| US-6103715-A | COMPOUNDS THAT BIND TO THE DOPAMINE D4 RECEPTOR AND THEIR USE AS ANXIOLYTIC AGENTS, TREATMENT FOR SCHIZOPHRENIA, AND DRUG SCREENING; SIDE EFFECT REDUCTIOON | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-15 | — | — | US | claimed |
| EP-0736024-A1 | N-HETEROBICYCLYL-PIPERAZINYL OR-PIPERADINYL TRICYCLIC DERIVATIVES USEFUL AS DOPAMINE RECEPTOR LIGANDS | Allelix Biopharmaceuticals Inc. (CA) | 1996-10-09 | — | — | EP | claimed |
| US-5538965-A | TREATMENT OF PSYCHOLOGICAL DISORDERS SUCH AS SCHIZOPHRENIA AND ANXIETY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1996-07-23 | — | — | US | claimed |
| WO-1995017400-A1 | N-HETEROBICYCLYL-PIPERAZINYL OR-PIPERADINYL TRICYCLIC DERIVATIVES USEFUL AS DOPAMINE RECEPTOR LIGANDS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1995-06-29 | — | — | WO | claimed |
| CN-121410139-A | Method for detecting related substances in dibenzo [ b, f ] [1,4] thiazepin-11- [10H ] ketone | 苏州第壹制药有限公司 | 2026-01-27 | — | — | CN | disclosed |
| CN-117402127-B | Preparation method of quetiapine intermediate | 苏州敬业医药化工有限公司 | 2025-11-25 | — | — | CN | disclosed |
| CN-120136813-A | Deuterium-labeled quetiapine fumarate isotope compound, preparation method thereof and food detection method | 曼哈格(上海)生物科技有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-119285628-A | Compounds for the treatment and prophylaxis of respiratory syncytial virus infection diseases | 石药集团中奇制药技术（石家庄）有限公司 | 2025-01-10 | — | — | CN | disclosed |
| CN-117402127-A | Preparation method of quetiapine intermediate | 苏州敬业医药化工有限公司 | 2024-01-16 | — | — | CN | disclosed |
| EP-0050212-A1 | 5-Substituted-9-cyane-methylene-dithieno(3,4-b:4',3'-e) azepines, process for their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1982-04-28 | — | — | EP | disclosed |
| EP-0035711-A2 | 10-Substituted-5-cyanomethylene-dibenzo-(a,d)cycloheptenes, process for their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1981-09-16 | — | — | EP | disclosed |
| EP-0035714-A2 | 10-Substituted-5-cyanomethylene-10,11-dihydro-dibenzo-(a,d)-cycloheptenes, process for their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1981-09-16 | — | — | EP | disclosed |
| US-4263207-A | ANTIALLERGENS | MERCK & CO., INC. (US) | 1981-04-21 | — | — | US | disclosed |
| US-4263207-A | ANTIALLERGENS | MERCK & CO., INC. (US) | 1981-04-21 | — | — | US | disclosed |
| US-3908010-A | Basically substituted heterocycles as anti-emetics | WANDER AG DR A | 1975-09-23 | — | — | US | disclosed |