Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | F9 | P00740 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19668458 | 1.00 | NOS2 (0.45) | NOS2SLC6A2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL19668710 | 0.80 | NOS2 (0.43) | NOS2SLC6A2CHRNB2CHRNA4SCN5A | |
| SCHEMBL28340863 | 0.77 | ALDH1A1 (0.40) | SLC6A2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11222940 | 0.76 | SLC6A4 (0.63) | SLC6A2HTR2AKCNH2SLC6A4SLC6A3 | |
| SCHEMBL27650890 | 0.76 | KCNA5 (0.40) | SLC6A2KCNH2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL11236550 | 0.76 | SLC6A4 (0.56) | SLC6A2HTR2AKCNH2SLC6A4SLC6A3 | |
| SCHEMBL19668463 | 0.76 | SLC6A4 (0.46) | NOS2SLC6A2HTR2AKCNH2SLC6A4 | |
| SCHEMBL28626450 | 0.76 | SLC6A2 (0.45) | SLC6A2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL15140316 | 0.75 | DYRK1A (0.43) | NOS2TAAR1KCNH2ALDH1A1CYP1A2 | |
| SCHEMBL19668509 | 0.74 | SLC6A2 (0.51) | NOS2SLC6A2HTR2ASCN5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0075752-B1 | SUBSTITUTED 2-PHENYL-2-(PYRIDYLOXY)-ETHYL AMINES AND ISOSTERIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE | BOEHRINGER INGELHEIM KG (DE) | 1986-03-12 | — | — | EP | claimed |
| EP-0075752-A2 | Substituted 2-phenyl-2-(pyridyloxy)-ethyl amines and isosteric compounds, process for their preparation and use | BOEHRINGER INGELHEIM KG (DE) | 1983-04-06 | — | — | EP | claimed |
| EP-1021411-B1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-6326386-B1 | ANTICOAGULANT | GLAXO GROUP LIMITED (GB) | 2001-12-04 | — | — | US | disclosed |
| EP-0075752-B1 | SUBSTITUTED 2-PHENYL-2-(PYRIDYLOXY)-ETHYL AMINES AND ISOSTERIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE | BOEHRINGER INGELHEIM KG (DE) | 1986-03-12 | — | — | EP | disclosed |
| EP-0075752-B1 | SUBSTITUTED 2-PHENYL-2-(PYRIDYLOXY)-ETHYL AMINES AND ISOSTERIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE | BOEHRINGER INGELHEIM KG (DE) | 1986-03-12 | — | — | EP | disclosed |
| EP-0075752-A2 | Substituted 2-phenyl-2-(pyridyloxy)-ethyl amines and isosteric compounds, process for their preparation and use | BOEHRINGER INGELHEIM KG (DE) | 1983-04-06 | — | — | EP | disclosed |
| EP-0075752-A2 | Substituted 2-phenyl-2-(pyridyloxy)-ethyl amines and isosteric compounds, process for their preparation and use | BOEHRINGER INGELHEIM KG (DE) | 1983-04-06 | — | — | EP | disclosed |
| EP-0075752-A2 | Substituted 2-phenyl-2-(pyridyloxy)-ethyl amines and isosteric compounds, process for their preparation and use | BOEHRINGER INGELHEIM KG (DE) | 1983-04-06 | — | — | EP | disclosed |