Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 11/20 | 0.33 |
| ▸ | CTSL | P07711 | 7/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | FAP | Q12884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695622 | 0.91 | CTSS (0.37) | CTSSCTSLCTSKCTSB | |
| SCHEMBL694304 | 0.87 | CTSS (0.42) | CTSSCTSLCTSKCTSB | |
| SCHEMBL693779 | 0.83 | CTSL (0.36) | CTSSCTSLCTSKCTSB | |
| SCHEMBL695487 | 0.83 | CTSS (0.44) | CTSSCTSLCTSKCTSB | |
| Hydrochloric Acid SCHEMBL695250 | 0.82 | CTSS (0.43) | CTSSCTSLCTSKCTSB | |
| SCHEMBL696530 | 0.78 | CTSS (0.39) | CTSSCTSLCTSKCTSB | |
| Hydrochloric Acid SCHEMBL695707 | 0.77 | CTSS (0.39) | CTSSCTSLCTSKCTSB | |
| SCHEMBL697241 | 0.76 | CTSL (0.37) | CTSSCTSLCTSB | |
| SCHEMBL695657 | 0.75 | CTSS (0.38) | CTSSCTSLCTSKCTSB | |
| SCHEMBL695639 | 0.75 | CTSS (0.39) | CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |