Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6739 | 0.91 | AKR1C3 (0.40) | S1PR1TRPV1TAS2R8S1PR3 | |
| SCHEMBL6965 | 0.85 | EPHX2 (0.39) | EPHX2PPARGS1PR1ALDH1A1P2RX7 | |
| SCHEMBL2627 | 0.82 | LPAR1 (0.39) | LPAR1CYP2C9 | |
| SCHEMBL6581 | 0.79 | CHRM1 (0.40) | EPHX2PPARGS1PR1ALDH1A1L3MBTL1 | |
| SCHEMBL1828 | 0.78 | LPAR1 (0.47) | PPARGTAS2R8P2RX7LPAR1CYP2C9 | |
| SCHEMBL6738 | 0.76 | AKR1C3 (0.39) | EPHX2PPARGS1PR1 | |
| SCHEMBL7041 | 0.74 | LPAR1 (0.37) | TAS2R8ALDH1A1L3MBTL1PKMLPAR1 | |
| SCHEMBL6024 | 0.72 | LPAR1 (0.46) | PPARGS1PR1ALDH1A1L3MBTL1PKM | |
| SCHEMBL6580 | 0.71 | PPARG (0.42) | EPHX2PPARGALDH1A1LPAR1KDM4E | |
| SCHEMBL2380 | 0.71 | ABCC3 (0.38) | TRPV1LPAR1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |