Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969588 | 0.88 | PPARG (0.47) | PPARGCYP3A4MEN1ALDH1A1TP53 | |
| SCHEMBL6976890 | 0.81 | PIM1 (0.47) | PPARGHPGD | |
| SCHEMBL6975119 | 0.81 | PIM1 (0.47) | PPARGHPGD | |
| SCHEMBL6974817 | 0.79 | MEN1 (0.50) | PPARGCYP3A4MEN1ALDH1A1TP53 | |
| SCHEMBL6967584 | 0.78 | MEN1 (0.49) | PPARGCYP3A4MEN1ALDH1A1TP53 | |
| SCHEMBL6976385 | 0.77 | CYP3A4 (0.46) | PPARGCYP3A4MEN1ALDH1A1TP53 | |
| SCHEMBL6964327 | 0.77 | CYP3A4 (0.46) | PPARGCYP3A4MEN1ALDH1A1TP53 | |
| SCHEMBL6964333 | 0.77 | CYP3A4 (0.46) | PPARGCYP3A4MEN1ALDH1A1TP53 | |
| SCHEMBL9632215 | 0.77 | MAPT (0.53) | PPARGCYP3A4MEN1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL6977644 | 0.76 | CYP3A4 (0.45) | PPARGCYP3A4MEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | claimed |
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |