Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28780507 | 0.84 | ALDH1A1 (0.32) | ALDH1A1KDM4EALOX15 | |
| SCHEMBL20768513 | 0.83 | MRGPRX4 (0.37) | TSHRSMN1; SMN2CASP1CYP1A2CLCN2 | |
| SCHEMBL1246006 | 0.82 | TSHR (0.57) | TSHRSMN1; SMN2CLCN2ALDH1A1MEN1 | |
| SCHEMBL30452631 | 0.82 | TSHR (0.57) | TSHRSMN1; SMN2CLCN2ALDH1A1MEN1 | |
| SCHEMBL27535204 | 0.82 | TSHR (0.39) | TSHRSMN1; SMN2CASP1CYP1A2CLCN2 | |
| SCHEMBL543047 | 0.82 | TSHR (0.45) | TSHRSMN1; SMN2CASP1CYP1A2CLCN2 | |
| SCHEMBL27308477 | 0.82 | CLCN2 (0.54) | TSHRSMN1; SMN2CASP1CYP1A2CLCN2 | |
| SCHEMBL6972148 | 0.80 | CLCN2 (0.40) | TSHRSMN1; SMN2CASP1CYP1A2CLCN2 | |
| Hydrochloric Acid SCHEMBL28243602 | 0.80 | CLCN2 (0.53) | TSHRSMN1; SMN2CASP1CYP1A2CLCN2 | |
| SCHEMBL217628 | 0.80 | TSHR (0.61) | TSHRSMN1; SMN2CASP1CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955294-B1 | Imidazolyl-alkenoic acid | SMITHKLINE BEECHAM CORP (US) | 2003-09-24 | — | — | EP | disclosed |
| EP-0955294-A2 | Imidazolyl-alkenoic acid | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-10 | — | — | EP | disclosed |