Sugi Predict

Sugi Predict / Compounds / SCHEMBL1246006

SCHEMBL1246006

SCHEMBL1246006

O=C(O)c1cccc(CBr)c1Cl

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.57
▸ ALDH1A1 P00352 3/20 0.45
▸ HMGB1 P09429 1/20 0.43
▸ FOLH1 Q04609 2/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ TP53 P04637 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ CLCN2 P51788 2/20 0.40
▸ LMNA P02545 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ MRGPRX4 Q96LA9 3/20 0.39
▸ ERCC5 P28715 1/20 0.39
▸ FEN1 P39748 1/20 0.39
▸ NR4A1 P22736 2/20 0.38
▸ NR4A2 P43354 1/20 0.38
▸ NR4A3 Q92570 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30452631 1.00 TSHR (0.57) TSHRALDH1A1HMGB1FOLH1ALOX15
SCHEMBL27830334 0.85 TSHR (0.53) TSHRALDH1A1HMGB1FOLH1ALOX15
SCHEMBL13622156 0.85 ALDH1A1 (0.39) TSHRALDH1A1HMGB1FOLH1ALOX15
SCHEMBL6935726 0.82 TSHR (0.59) TSHRALDH1A1HMGB1FOLH1ALOX15
SCHEMBL28204201 0.82 TSHR (0.59) TSHRALDH1A1HMGB1FOLH1ALOX15
SCHEMBL6966009 0.82 TSHR (0.44) TSHRALDH1A1ALOX15TP53HTT
SCHEMBL1245932 0.81 TSHR (0.62) TSHRALDH1A1HMGB1FOLH1ALOX15
SCHEMBL15592534 0.80 TSHR (0.52) TSHRALDH1A1HMGB1FOLH1ALOX15
SCHEMBL4448226 0.80 ALDH1A1 (0.46) TSHRALDH1A1HMGB1FOLH1ALOX15
SCHEMBL445508 0.79 FOLH1 (0.59) TSHRALDH1A1HMGB1FOLH1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257041-A1 INDUCERS OF INTEGRATED STRESS RESPONSE TO TREAT CANCER THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2025-08-14 — — US disclosed
EP-4526291-A1 INDUCERS OF INTEGRATED STRESS RESPONSE TO TREAT CANCER The Board of Regents of the University of Texas System (US) 2025-03-26 — — EP disclosed
WO-2023225327-A1 INDUCERS OF INTEGRATED STRESS RESPONSE TO TREAT CANCER THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-11-23 — — WO disclosed
CN-111253404-B Nitrogen-containing heterocyclic compound and composition, preparation method and application thereof 上海医药集团股份有限公司 2023-05-23 — — CN disclosed
EP-2459572-B1 SPIROCYCLIC AMIDE DERIVATIVES ASTRAZENECA AB (SE) 2018-09-12 — — EP disclosed
US-8629271-B2 Compounds ASTRAZENECA AB (GB) 2014-01-14 — — US disclosed
US-8476265-B2 Compounds-801 ASTRAZENECA AB (SE) 2013-07-02 — — US disclosed
US-8476265-B2 Compounds-801 ASTRAZENECA AB (SE) 2013-07-02 — — US disclosed
US-8476265-B2 Compounds-801 ASTRAZENECA AB (SE) 2013-07-02 — — US disclosed
US-8455483-B2 Compounds—801 ASTRAZENECA AB (SE) 2013-06-04 — — US disclosed
US-7622612-B2 Tricyclic derivatives and their use CHEMTECH RESEARCH INCORPORATION (KR) 2009-11-24 — — US disclosed
WO-2009098448-A1 COMPOUNDS ASTRAZENECA AB (SE) 2009-08-13 — — WO disclosed
US-20070021427-A1 Novel tricyclic derivatives and their use CHEMTECH RESEARCH INCORPORATION (KR) 2007-01-25 — — US disclosed
US-20070021427-A1 Novel tricyclic derivatives and their use CHEMTECH RESEARCH INCORPORATION (KR) 2007-01-25 — — US disclosed
US-20070021427-A1 Novel tricyclic derivatives and their use CHEMTECH RESEARCH INCORPORATION (KR) 2007-01-25 — — US disclosed
EP-0107693-B1 2,3,4-TRINOR-1,5-INTER-M-PHENYLENE-PROSTACYCLIN-I2 ANALOGUES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1988-07-27 — — EP disclosed
US-4638002-A ANTIAGGLOMERANTS, HYPOTENSIVE, ANTISECRETORY, ANTISPASMODIC, ANTIULCER, BRONCHODILATOR, ANTIHISTAMINES CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1987-01-20 — — US disclosed
EP-0107693-A4 2,3,4-TRINOR-1,5-INTER-M-PHENYLENE-PROSTACYCLIN-I2 ANALOGUES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. CHINOIN GYOGYSZER ES VEGYESZET (HU) 1984-09-17 — — EP disclosed
EP-0107693-A1 2,3,4-TRINOR-1,5-INTER-M-PHENYLENE-PROSTACYCLIN-I2 ANALOGUES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. CHINOIN GYOGYSZER ES VEGYESZET (HU) 1984-05-09 — — EP disclosed
WO-1983004021-A1 2,3,4-TRINOR-1,5-INTER-M-PHENYLENE-PROSTACYCLINE-I2 ANALOGUES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. (HU) 1983-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257041-A1 INDUCERS OF INTEGRATED STRESS RESPONSE TO TREAT CANCER DDIT3, ATF4, EIF2AK3 TSHR 4131/4885ALDH1A1 4205/4885HMGB1 1112/4885
US-20070021427-A1 Novel tricyclic derivatives and their use NFATC1, IL2, CCL2 TSHR 4563/4885ALDH1A1 2078/4885HMGB1 310/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.