Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966803 | 0.91 | SLC6A4 (0.48) | GRM2SLC6A4 | |
| SCHEMBL6967736 | 0.91 | SLC6A4 (0.48) | GRM2SLC6A4 | |
| SCHEMBL6964919 | 0.91 | SLC6A4 (0.48) | GRM2SLC6A4 | |
| SCHEMBL5527597 | 0.90 | CYP2D6 (0.52) | CYP2D6ADRA1DSLC6A4 | |
| SCHEMBL6962326 | 0.90 | SLC6A4 (0.47) | SLC6A4 | |
| SCHEMBL6962409 | 0.88 | CYP2D6 (0.48) | CCR2CYP2D6ADRA1DSLC6A4 | |
| SCHEMBL6961404 | 0.88 | CYP2D6 (0.48) | CYP2D6ADRA1DSLC6A4 | |
| SCHEMBL6968341 | 0.88 | OPRM1 (0.52) | GRM2SLC6A4 | |
| SCHEMBL6965715 | 0.88 | OPRM1 (0.52) | GRM2SLC6A4 | |
| SCHEMBL6956398 | 0.88 | DRD2 (0.49) | GRM2ADRA1DSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964863-B1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 2003-05-21 | — | — | EP | disclosed |
| US-6462056-B1 | SUCH AS 3-(4-CHLOROPHENYL)-5-(4-(3-INDOLYL)-1-PIPERIDINYL-METHYL)OXAZOLIDIN-2-ONE; 5-HT2A ANTAGONISTS WITH 5-HT REUPTAKE INHIBITING, ANTIDEPRESSANT OR ANXIOLYTIC EFFECT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-10-08 | — | — | US | disclosed |
| EP-0964863-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998038189-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-03 | — | — | WO | disclosed |