SCHEMBL6966808

SCHEMBL6966808

CS(=O)(=O)NCCC(c1ccco1)C1CCCCC(=N)N1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.35
POLB P06746 3/20 0.35
MAPT P10636 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
LMNA P02545 3/20 0.33
NPSR1 Q6W5P4 2/20 0.33
KMT2A Q03164 1/20 0.33
GFER P55789 1/20 0.32
HTT P42858 3/20 0.31
GAA P10253 2/20 0.31
TP53 P04637 1/20 0.31
ALOX15 P16050 2/20 0.31
MAPK1 P28482 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6977392 0.80 ALDH1A1 (0.37) ALDH1A1POLB
SCHEMBL6978293 0.77 ALDH1A1 (0.39) ALDH1A1POLBTP53
SCHEMBL6977874 0.77 ALDH1A1 (0.43) ALDH1A1POLBMAPTNPSR1TP53
SCHEMBL6970982 0.75 MEN1 (0.35) ALDH1A1TDP1LMNAKMT2A
SCHEMBL6977560 0.74 ALDH1A1 (0.37) ALDH1A1POLB
Trifluoroacetic Acid SCHEMBL6981240 0.71 ALDH1A1 (0.41) ALDH1A1POLBKMT2ATP53
SCHEMBL6976352 0.71 ALDH1A1 (0.42) ALDH1A1POLBMAPTKMT2AGAA
SCHEMBL6981063 0.66 ALDH1A1 (0.31) ALDH1A1POLBMAPTTDP1LMNA
SCHEMBL6978310 0.65 ALDH1A1 (0.41) ALDH1A1POLBTP53ALOX15MAPK1
SCHEMBL6970067 0.65 KMT2A (0.43) ALDH1A1POLBMAPTTDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0821674-B1 CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS SEARLE & CO (US) 2003-08-06 EP claimed
US-6011028-A Cyclic amidino agents useful as nitric oxide synthase inhibitors G.D. SEARLE & CO. (US) 2000-01-04 US claimed
US-5883251-A ENZYME INHIBITORS G. D. SEARLE & CO. (US) 1999-03-16 US claimed
EP-0821674-A1 CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G.D. SEARLE & CO. (US) 1998-02-04 EP claimed
WO-1996033175-A1 CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G.D. SEARLE & CO. (US) 1996-10-24 WO claimed
EP-0821674-B1 CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS SEARLE & CO (US) 2003-08-06 EP disclosed
US-6043261-A TREATMENT OF INFLAMMATORY CONDITIONS AFFECTING THE JOINTS, FOR EXAMPLE ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CARDIOVASCULAR ISCHEMIA, DIABETES, HYPERALGESIA, CEREBRAL ISCHEMIA, THROMBOTIC STROKE, GLOBAL ISCHEMIA, NERVOUS SYSTEM DISORDERS G. D. SEARLE & CO. (US) 2000-03-28 US disclosed
US-6011028-A Cyclic amidino agents useful as nitric oxide synthase inhibitors G.D. SEARLE & CO. (US) 2000-01-04 US disclosed
US-5883251-A ENZYME INHIBITORS G. D. SEARLE & CO. (US) 1999-03-16 US disclosed
EP-0821674-A1 CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G.D. SEARLE & CO. (US) 1998-02-04 EP disclosed
WO-1996033175-A1 CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G.D. SEARLE & CO. (US) 1996-10-24 WO disclosed