Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656090 | 0.89 | CYP11B2 (0.50) | CYP11B2CYP11B1DRD2KCNH2NR3C1 | |
| SCHEMBL6657591 | 0.88 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1CYP17A1HTR1D | |
| SCHEMBL6846125 | 0.88 | CYP11B2 (0.59) | CYP11B2CYP11B1CYP19A1CYP17A1MAPT | |
| SCHEMBL6847800 | 0.87 | CYP11B2 (0.51) | CYP11B2CYP11B1CYP19A1CYP17A1MAPT | |
| SCHEMBL16356718 | 0.86 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1CYP17A1HTR1D | |
| SCHEMBL6966311 | 0.85 | KCNH2 (0.52) | CYP11B2CYP11B1DRD2KCNH2NR3C1 | |
| SCHEMBL6657585 | 0.84 | CYP11B2 (0.48) | CYP11B2CYP11B1CYP19A1CYP17A1MAPT | |
| SCHEMBL6957036 | 0.83 | KCNH2 (0.54) | DRD2KCNH2NR3C1CYP19A1PGR | |
| SCHEMBL6845463 | 0.83 | CYP11B2 (0.55) | CYP11B2CYP11B1CYP19A1CYP17A1MAPT | |
| SCHEMBL16356490 | 0.82 | CYP11B1 (0.48) | CYP11B2CYP11B1NR3C1CYP19A1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |