Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.54 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846125 | 0.94 | CYP11B2 (0.59) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 | |
| SCHEMBL22515743 | 0.93 | CYP11B2 (0.53) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 | |
| SCHEMBL6655119 | 0.93 | CYP11B2 (0.51) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 | |
| SCHEMBL22515748 | 0.90 | CYP11B2 (0.49) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 | |
| SCHEMBL6966876 | 0.88 | CYP11B2 (0.53) | CYP11B2CYP11B1CYP19A1CYP17A1HTR1D | |
| SCHEMBL16356490 | 0.88 | CYP11B1 (0.48) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 | |
| SCHEMBL16356718 | 0.87 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 | |
| SCHEMBL6657897 | 0.85 | CYP11B2 (0.55) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 | |
| SCHEMBL6845959 | 0.85 | CYP11B1 (0.54) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 | |
| SCHEMBL6847800 | 0.85 | CYP11B2 (0.51) | CYP11B2CYP11B1CYP19A1CYP17A1NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | BAYER PHARMACEUTICALS CORPORATION | 2004-11-25 | — | — | US | disclosed |
| EP-1432698-A2 | SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027094-A2 | SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | CYP17A1, IDO1, CYP21A2 | CYP11B2 53/4885CYP11B1 30/4885CYP19A1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.