Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27353880 | 0.86 | KCNH2 (0.39) | KCNH2MEN1KMT2ARCE1LPAR1 | |
| SCHEMBL6968330 | 0.85 | KCNH2 (0.38) | KCNH2MEN1KMT2ARCE1LPAR1 | |
| SCHEMBL6967185 | 0.84 | KCNH2 (0.58) | KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL6967760 | 0.83 | RCE1 (0.49) | MEN1KMT2ARCE1LPAR1LPAR5 | |
| SCHEMBL6956260 | 0.83 | RCE1 (0.49) | MEN1KMT2ARCE1LPAR1LPAR5 | |
| SCHEMBL6961141 | 0.76 | RIPK1 (0.43) | KCNH2MEN1KMT2ALPAR1MAOB | |
| SCHEMBL7599280 | 0.75 | LPAR1 (0.43) | KCNH2ALDH1A1RCE1LPAR1LPAR5 | |
| SCHEMBL6961676 | 0.73 | MLYCD (0.47) | KCNH2MLYCDMAOBTAAR1 | |
| SCHEMBL6968790 | 0.73 | KDM4E (0.47) | MEN1KMT2AALDH1A1RCE1MAOB | |
| SCHEMBL9799345 | 0.72 | MAOB (0.57) | MAOBTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |