SCHEMBL6966941

SCHEMBL6966941

COc1ccc(COCc2nc(C(C)C)c[nH]2)cc1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.42
AGXT P21549 2/20 0.42
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
TAAR1 Q96RJ0 1/20 0.39
SLC6A4 P31645 1/20 0.37
TDP1 Q9NUW8 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HTT P42858 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
TBXAS1 P24557 1/20 0.36
APP P05067 3/20 0.36
MAOB P27338 1/20 0.35
HCAR2 Q8TDS4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4903117 0.84 TSHR (0.46) IDO1AGXTCA1CA2ALDH1A1
SCHEMBL6963019 0.73 APP (0.40) IDO1AGXTCA1CA2SLC6A4
SCHEMBL34413 0.73 IDO1 (0.67) IDO1AGXTCA1CA2TAAR1
SCHEMBL4901240 0.72 HRH4 (0.44) TDP1ALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL10727102 0.72 IDO1 (0.55) IDO1AGXTCA1CA2SLC6A4
Hydrochloric Acid SCHEMBL28912134 0.71 IDO1 (0.68) IDO1AGXTCA1CA2TAAR1
Potassium SCHEMBL1477050 0.71 IDO1 (0.64) IDO1AGXTCA1CA2TAAR1
Methoxymethane SCHEMBL28823290 0.71 IDO1 (0.64) IDO1AGXTCA1CA2TAAR1
Bromide SCHEMBL28558295 0.71 IDO1 (0.64) IDO1AGXTCA1CA2TAAR1
SCHEMBL1475481 0.71 IDO1 (0.64) IDO1AGXTCA1CA2TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed