SCHEMBL6963019

SCHEMBL6963019

COc1ccc(COCc2nc(C(C)C)c(I)[nH]2)cc1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
APP P05067 3/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
HCAR2 Q8TDS4 1/20 0.38
IDO1 P14902 2/20 0.37
AGXT P21549 2/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
SLC6A4 P31645 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TBXAS1 P24557 1/20 0.34
TYMP P19971 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6962307 0.76 CYP1A2 (0.35) CA1CA2HCAR2IDO1AGXT
SCHEMBL29668096 0.75
SCHEMBL6973717 0.73 LMNA (0.35) HCAR2
SCHEMBL6966941 0.73 IDO1 (0.42) APPCA1CA2HCAR2IDO1
Water SCHEMBL5212293 0.72 ALDH1A1 (0.40) HCAR2NPC1RAB9ASMN1; SMN2TDP1
SCHEMBL34413 0.71 IDO1 (0.67) APPCA1CA2IDO1AGXT
SCHEMBL10727102 0.70 IDO1 (0.55) APPCA1CA2IDO1AGXT
SCHEMBL14439851 0.69 TSHR (0.41) CA1CA2HCAR2NPC1RAB9A
Potassium SCHEMBL1477050 0.69 IDO1 (0.64) APPCA1CA2IDO1AGXT
Hydrochloric Acid SCHEMBL28912134 0.69 IDO1 (0.68) APPCA1CA2IDO1AGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed